ARN3236
Catalogue number:
CAY31457-10 mg
Supplier:
Size:
10 mg
Product is available in:
£388.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1613710-01-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
336.4
Alternative Names:
3-(2,4-dimethoxyphenyl)-4-(3-thienyl)-1h-pyrrolo[2,3-b]pyridine
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of SIK2 (IC50 = 50s = 21.63 and 6.63 nM, respectively); inhibits TNF-α secretion in RAW 264.7 cells (IC50 = ~2.5 µM) and reduces phosphorylation of CRTC3 and HDAC4 in macrophages at 3 µM; inhibits growth of 10 ovarian cancer cell lines (IC50s = 0.8-2.6 µM) and increases sensitivity of eight of them to paclitaxel; halts the cell cycle at the G2/M phase and induces apoptosis and tetraploidy in SKOV3 cells at 1 µM; has an additive effect on reducing tumor growth when used in combination with paclitaxel in an ovarian cancer mouse xenograft model at 60 mg/kg per day
Storage Temperature:
-20°C