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876310-60-0
≥98%
A solid
482.6
n2-(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)-l-arginyl-l-phenylalaninamide
- Data sheet: View or download
- MSDS: View or download
An NPFF receptor antagonist; binds to human NPFF1 and NPFF2 receptors (Kis = 58 and 75 nM, respectively); selective for NPFF1 and NPFF2 receptors over NPY receptor Y1, GPR10, GPR54, GPR103, ORL-1, and µ-, δ-, and κ-opioid receptors at 10 µM; inhibits NPFF-induced [35S]GTPγS binding to the NPFF2 receptor at 7.5 µM; reverses NPVF-induced inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing the human NPFF1 receptor (EC50 = 4.7 µM); inhibits NPFF-induced increases in mean arterial pressure and heart rate in rats at 10 µg, i.c.v.; prevents heroin-induced delayed hyperalgesia and associated tolerance in rats at 0.1 mg/kg, s.c.
-20°C