TAS 103 (hydrochloride)
Catalogue number:
CAY29869-10 mg
Supplier:
Size:
10 mg
Product is available in:
£157.00
Estimated delivery Tue 6 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
174634-09-4
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
406.3
Alternative Names:
6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7h-indeno[2,1-c]quinolin-7-one, dihydrochloride
- Data sheet: View or download
- MSDS: View or download
Product Description:
A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models
Storage Temperature:
-20°C