£1076.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1202055-32-0
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
676.7
Alternative Names:
n-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amino]-1h-pyrazolo[4,3-h]quinazoline-3-carboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An Mps1/TTK inhibitor (IC50 = 0.182 µM); selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all); accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells; induces aneuploidy and apoptosis in A2780 ovarian cancer cells at 1 µM, as well as inhibits proliferation in a panel of 127 cancer cell lines (IC50s = 0.192-10 µM); reduces tumor growth in an A2780 mouse xenograft model at 90 mg/kg per day
Storage Temperature:
-20°C