£691.00
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1813527-81-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
499.5
Alternative Names:
4-[4-fluoro-3-[[(2-pyridinylmethyl)amino]carbonyl]phenyl]-1,2,3,4-tetrahydro-n-1h-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A GRK inhibitor (IC50s = 3.9, 0.15, and 0.38 µM for GRK1, GRK2, and GRK5, respectively); selective for GRKs over PKA (IC50 = 120 µM); increases contractility in isoproterenol-stimulated isolated mouse cardiomyocytes at 500 nM; prevents the desensitization of histamine H1 receptor- and purinergic P2Y2 receptor-driven phospholipase C signaling in human ULTR myometrial cells and isolated rat MSMCs, respectively (IC50s = 3.09 and 2.95 µM, respectively)
Storage Temperature:
-20°C