£42.00
Estimated delivery Tue 27 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
931314-31-7
Purity:
≥90%
Formulation:
A solid
Molecular Formula:
C21H25N3O4S
Molecular Weight:
415.5
Alternative Names:
1-(2,5-dimethoxyphenyl)-4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-5-methyl-1h-1,2,3-triazole, specific pxr antagonist 70
- Data sheet: View or download
- MSDS: View or download
Product Description:
A PXR antagonist (IC50 = 0.51 µM); selective for PXR over 10 additional nuclear receptors at >5 µM, as well as over a panel of 384 kinases at 10 µM; inhibits rifampicin-induced PXR activation from 0.1-10 µM; inhibits rifampicin-induced CYP3A4 activity in primary human hepatocytes; inhibits PXR agonist-induced CYP3A4-mediated metabolism of midazolam and paclitaxel in hPXR-tg mice at 200 mg/kg
Storage Temperature:
-20°C