This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2290527-07-8
Purity:
99.7
Molecular Formula:
C25H23FN4O
Molecular Weight:
414.47
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)