This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1353552-97-2
Purity:
98.01
Molecular Formula:
C26H26N6O3
Molecular Weight:
470.52
Alternative Names:
HM71224; LY3337641
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Poseltinib, an orally active, selective and irreversible Bruton’s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively. Poseltinib can covalently bind to the active site (cysteine 481 residue) of BTK, and reveales potent inhibition of B cell receptor (BCR), Fc receptor (FcR), Toll-like receptor (TLR) mediated signaling[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)