This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2502156-03-6
Purity:
95
Molecular Formula:
C59H71ClFN11O7S
Molecular Weight:
1132.78
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 µM[1]. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines[2].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)