This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
459-86-9
Purity:
99.33
Molecular Formula:
C5H12N8
Molecular Weight:
184.2
Alternative Names:
Methylglyoxal-bis(guanylhydrazone); MGBG; Methyl-GAG
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
Mitoguazone (Methylglyoxal-bis(guanylhydrazone)) is a synthetic polycarbonyl derivative with potent antineoplastic activity. Mitoguazone is a brain-penetrant and competitive S-adenosyl-methionine decarboxylase (SAMDC) inhibitor that disrupts polyamine biosynthesis. Mitoguazone induces cell apoptosis. Mitoguazone inhibits HIV DNA integration into the cellular DNA in both monocytes and macrophages. Mitoguazone has the potential for acute leukemia, Hodgkin's and non-Hodgkin's lymphoma treatment[1][2][3][4].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)