This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1957203-01-8
Purity:
98.03
Molecular Weight:
515.61
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
YKL-5-124 is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH, respectively. YKL-5-124 is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)