Koumine
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1358-76-5
≥98%
A solid
306.4
(3s,4s,4ar,6r,11bs,11cs)-11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-6,4-(epoxymethano)-3,11b-methano-11bh-pyrido[4,3-c]carbazole
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- MSDS: View or download
An alkaloid with diverse biological activities; inhibits the proliferation of MCF-7 cells (IC50 = 124 µg/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells; reduces LPS-induced increases in iNOS, IL-1β, IL-6, and TNF-α levels in RAW 264.7 macrophages at 200 and 400 µg/ml; inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice at 2 and 10 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, at 0.4-10 mg/kg
-20°C