ZZW-115
Catalogue number:
CAY34974-5 mg
Supplier:
Size:
5 mg
Product is available in:
£358.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
10122-45-9
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
574
Alternative Names:
n,n-dimethyl-4-[3-[2-(trifluoromethyl)-10h-phenothiazin-10-yl]propyl]-1-piperazineethanamine, trihydrochloride
- Data sheet: View or download
- MSDS: View or download
Product Description:
A NUPR1 inhibitor; binds to NUPR1 (Kd = 2.1 µM) in a cell-free assay; cytotoxic against a panel of 11 pancreatic ductal adenocarcinoma cell lines (IC50s = 0.84-4.93 µM), as well as against a panel of 16 additional cancer cell lines, including glioblastoma, lymphoma, and leukemia cells (IC50s =0.25-7.75 µM); induces apoptosis and necrosis in MiaPaCa-2, LIPC, Foie8b, 02-063, and HN14 pancreatic cancer cells at 3 and 5 µM; induces ROS accumulation, lipid peroxidation, and ferroptosis in MiaPaCa-2 cells; reduces tumor growth in a MiaPaCa-2 mouse xenograft model at 1, 2.5, or 5 mg/kg
Storage Temperature:
-20°C