£159.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
24533-47-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
298.3
Alternative Names:
(2e)-3-(2,3-dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of the MD-2 and TLR4 interaction; binds to MD-2 (Kd = 33.3 µM in a cell-free assay); inhibits the protein-protein interaction between MD-2 and TLR4 in LPS-stimulated ECV304 cells; decreases the migration of LPS-stimulated HCT116 cells at 10 µM; inhibits LPS-induced increases in the production of TNF-α and IL-6 in mouse primary macrophages (IC50s = 6.17 and 7.72 µM, respectively); increases survival in a mouse model of LPS-induced sepsis; increases cardiac levels of GPX4 and decreases cardiac mitochondrial ROS in rats fed a high-fat diet
Storage Temperature:
-20°C