BQ-788
Shipping is calculated in checkout
173326-37-9
≥90%
641.8
n-[(cis-2,6-dimethyl-1-piperidinyl)carbonyl]-4-methyl-l-leucyl-1-(methoxycarbonyl)-d-tryptophyl-d-norleucine
- Data sheet: View or download
- MSDS: View or download
A peptide ETB receptor antagonist (IC50 = 1.2 nM); selective for ETB over ETA receptors (IC50 = 280 nM), as well as angiotensin, calcitonin, or neuropeptide receptors at 10 µM; inhibits ET-1-induced calcium mobilization in human Girrardi heart cells (IC50 = 0.54 nM) and BQ-3020-induced vasoconstriction in isolated rat pulmonary arteries (pA2 = 8.4); inhibits ET-1 induced depressor responses and induces pressor responses in rats at 1 mg/kg; protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats; attenuates delayed hypotension, vascular hyporeactivity to norepinephrine, and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemia
-20°C