Sorafenib (tosylate)
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475207-59-1
≥98%
A solid
637
4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-n-methyl-2-pyridinecarboxamide, 4-methylbenzenesulfonate, bay 43-9006 mono-p-tosylate, bay 54-9085
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- MSDS: View or download
A multi-kinase inhibitor; inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively); inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively); selective for these kinases over 12 other kinases (IC50s = >10 µM for all); inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively); inhibits tumor growth in a PLC/PRF/5 mouse xenograft model at 30 mg/kg; induces ferroptotic cell death in HT-1080 fibrosarcoma cells at 10 µM but not in a variety of other cancer cell lines; inhibits HCV replication in Huh7.5 cells (IC50 = 7.2 µM)
-20°C