Hinokiflavone
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19202-36-9
≥95%
A solid
538.5
6-[4-(5,7-dihydroxy-4-oxo-4h-1-benzopyran-2-yl)phenoxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
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- MSDS: View or download
A biflavonoid with diverse biological activities; inhibits the aggregation of Aβ40 in vitro (IC50 = 9.5 µM); promotes pre-mRNA splicing of the genes encoding Mcl-1 and eIF4α and inhibits pre-mRNA splicing of the genes encoding Hsp40 and RIOK3 in NB4 cells at 10 µM; increases protein SUMOylation in HEK293 cells at 10 µM; reduces the cytopathic effect of the influenza A subtypes H1N1 and H1N3, influenza B, parainfluenza type 3, and RSV (IC50s = 1.4, 1.3, 1.2, 1, and 2.5 µg/ml, respectively); inhibits the migration and invasion of, and induces apoptosis in, KYSE-150 cells from 10-40 µM; reduces tumor volume in a KYSE-150 mouse xenograft model at 25 or 50 mg/kg
-20°C