ONO-8711 (dicyclohexylamine salt)
Catalogue number:
CAY38432-5 mg
Supplier:
Size:
5 mg
Product is available in:
£435.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
621.3
Alternative Names:
6-[(2r,3s)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5z-hexenoic acid, dicyclohexylamine salt
- Data sheet: View or download
- MSDS: View or download
Product Description:
An EP1 receptor antagonist (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells); is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells); inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively); reduces the incidence of squamous cell carcinoma and severe dysplasia induced by 4-nitroquinoline 1-oxide in a rat model of tongue carcinogenesis at 400 and 800 ppm in the diet
Storage Temperature:
-20°C