CAY10723 (hydrochloride)
Catalogue number:
CAY38018-500 ug
Supplier:
Size:
500 µg
Product is available in:
£131.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
503
Alternative Names:
n-[(1s)-4-[(2-fluoro-1-iminoethyl)amino]-1-(4-methoxy-1-methyl-1h-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo-1h-isoindole-4-carboxamide, monohydrochloride, afm30a, amf30a
- Data sheet: View or download
- MSDS: View or download
Product Description:
A PAD2 inhibitor (EC50 = 9.5 µM in a cellular target engagement assay); ~1.6-, ~47-, and ~15-fold selective for PAD2 over PAD1, PAD3, and PAD4, respectively; inhibits histone H3 citrullination in HEK293T cells expressing human PAD2 (EC50 = 0.4 µM); inhibits fibrinogen citrullination in the presence of isolated human PMNs or synovial fluid from patients with rheumatoid arthritis at 20 µM; decreases IFN-γ production in isolated human CD4+ T cells at 25 µM
Storage Temperature:
-20°C