DUBs-IN-2
Catalogue number:
CAY36229-5 mg
Supplier:
Size:
5 mg
Product is available in:
£277.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
924296-19-5
Purity:
≥95% (mixture of cis/trans isomers)
Formulation:
A solid
Molecular Weight:
275.3
Alternative Names:
9-(ethoxyimino)-9h-indeno[1,2-b]pyrazine-2,3-dicarbonitrile, deubiquitinase inhibitor 2, dubs inhibitor 2, hy-50737a
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of USP8 (IC50 = 280 nM); selective for USP8 over USP7 (IC50 = >100 µM); increases the level of PD-L1 in H460 cells at 2 µM and PC-9 cells at 2 and 4 µM; decreases tumor weight, tumor size, and lung metastasis and increases CD8+ T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day, i.p., when combined with an anti-PD-L1 antibody and paclitaxel
Storage Temperature:
-20°C