YM-244769 (dihydrochloride)
Catalogue number:
HY-136182-10mg
Supplier:
Size:
10 mg
Product is available in:
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1780390-65-9
Purity:
99.02
Molecular Weight:
516.39
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].
Storage Temperature:
4°C (Powder, sealed storage, away from moisture)