CAS Number:
1247819-59-5
Purity:
≥98% by HPLC.
Molecular Weight:
315.3
Product Description:
P22077 is a cell permeable inhibitor of the ubiquitin-specific protease USP7 (IC50=8.6 µM), and the closely related deubiquitinase (DUB) USP47. P22077 showed weak or no inhibition (EC50 >50µM) towards a panel of 14 isopeptidases and other proteases. Treatment of cells with P22077 (20-40 µM) causes an accumulation of K48-linked ubiquitinated species, and down regulation of the USP7 targets HDM2 and claspin.
Storage Temperature:
Store at 4°C. Stable as supplied for up to 2 years when stored dessicated at 4°C. Store solutions at