CAS Number:
668467-91-2
Purity:
≥98% by TLC.
Molecular Weight:
397.6
Product Description:
LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.
Storage Temperature:
Store at 4°C. Stable as supplied for up to 2 years when stored dessicated at 4°C. Store solutions at