b-AP15 (NSC-687852)
Catalogue number:
BPS-27701-1
Supplier:
Size:
5 mg _$$_
Product is available in:
CAS Number:
1009817-63-3
Purity:
≥98% by HPLC.
Molecular Weight:
419.4
Product Description:
Blocks 26S proteasome activity by inhibiting the ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) activities of the 19S regulatory subunit without affecting the catalytic activity of the 20S core subunit. b-AP15 displays several differences to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in four solid tumor models.