£627.00
Estimated delivery Tue 16 Jul
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1515888-53-5
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
423.5
Alternative Names:
1-[(2,5-dimethylphenyl)methyl]-6-(1-methyl-1h-pyrazol-4-yl)-α-4-pyridinyl-1h-benzimidazole-2-methanol
- Data sheet: View or download
- MSDS: View or download
Product Description:
A TNF inhibitor; binds to trimeric TNF (Kd = 13.8 nM); selectively increases the thermal stability of the TNF trimer over 10 other TNF superfamily members at 100 µM; inhibits TNF-induced NF-κB activity in a reporter assay using HEK293 cells and TNF-induced cytotoxicity in L-929 fibroblasts (IC50s = 202 and 116 nM, respectively); reduces TNF-induced peritoneal neutrophil recruitment in mice at 30-300 mg/kg, p.o.; decreases disease severity in a mouse model of collagen antibody-induced arthritis at 150 mg/kg, i.p.
Storage Temperature:
-20°C