£199.00
Estimated delivery Tue 16 Jul
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2259624-71-8
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
490.9
Alternative Names:
1-[(2-chloro-6-fluorophenyl)methyl]-2,3-dihydro-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-1h-indole-6-carboxamide, sting agonist-12
- Data sheet: View or download
- MSDS: View or download
Product Description:
A STING agonist; activates human wild-type STING (EC50 = 185 nM), as well as STING containing the polymorphisms R232, H232, or HAQ in HEK293 cells in an ISG54 luciferase reporter assay at 10 µM; induces the expression of IFN-α, IFN-β, TNF-α, CXCL10, IL-12p40, and IL-6 in isolated hMO-DCs at 10 µM; increases the expression of the dendritic cell markers CD83 and CD86 in hMO-DCs at 10 µM
Storage Temperature:
-20°C