This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2098211-50-6
Purity:
98.93
Molecular Weight:
492.5
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
I-138 is an orally active compound structurally related to ML323 (HY-17543). I-138 and ML-323 are potent reversible inhibitors of USP1-UAF1. I-138 displays synergistic binding with ubiquitin and mutual exclusive binding with ML323. I-138 induces the monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells, increases PCNA and FANCD2 monoubiquitination in HAP-1 USP1 WT cells. I-138 ablates USP1 autocleavage in cells[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)