TGR5 Receptor Agonist
Catalogue number:
CAY16291-5 mg
Supplier:
Size:
5 mg
Product is available in:
£159.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1197300-24-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
361.2
Alternative Names:
3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-4-isoxazolecarboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An agonist of the bile acid G protein-coupled receptor TGR5 (EC50s = 31.6-158.5 nM in cell-based assays); stimulates cAMP formation in HEK293 cells expressing TGR5 (EC50 = 2.3 pM); increases GLP-1 secretion and decreases glucose levels in the hepatic portal vein in dogs at 1 mg/kg when administered in combination with glucose; inhibits the CYP isozymes CYP2C19 and CYP3A4 (IC50s = 316.2 and 1,259 nM, respectively)
Storage Temperature:
-20°C
