CC-115
Catalogue number:
CAY19420-5 mg
Supplier:
Size:
5 mg
Product is available in:
£181.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1228013-15-7
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
336.4
Alternative Names:
1-ethyl-3,4-dihydro-7-[2-methyl-6-(1h-1,2,4-triazol-5-yl)-3-pyridinyl]-pyrazino[2,3-b]pyrazin-2(1h)-one
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual inhibitor of mTOR and DNA-PK (IC50s = 0.021 and 0.013 µM, respectively); selective for mTOR and DNA-PK over PI3Kα, ATM, and ATR (IC50s = 0.85, >30, and >30 µM, respectively); inhibits growth in a panel of 123 cancer cell lines, including breast, head and neck, and lung cancer cells (GI50s = 0.015-1.77 µM); inhibits NHEJ in CAL-51, MDA-MB-231, PC3, and HCT116 cells (IC50s = 3.15, 2.16, 2.72, and 6.35 µM, respectively); reduces tumor growth in a PC3 prostate cancer mouse xenograft model at 0.25, 0.5, and 1 mg/kg twice per day
Storage Temperature:
-20°C
