Arglabin
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84692-91-1
≥98%
A crystalline solid
246.3
(3ar,4as,6as,9as,9br)-5,6,6a,7,9a,9b-hexahydro-1,4a-dimethyl-7-methylene-3h-oxireno[8,8a]azuleno[4,5-b]furan-8(4ah)-one
- Data sheet: View or download
- MSDS: View or download
A sesquiterpene γ-lactone; inhibits the growth of LS-180, SSC-4, HeLa, MCF-7, and HL-60 cancer cells (IC50s = 20, 10, 20, 20, and 50 µM, respectively); reduces tumor growth in an SCC-4 mouse xenograft model at 40 µg/g; reduces protein levels of NLRP3, caspase-1, IL-1β, and IL-18 induced by cholesterol crystals in LPS-primed mouse peritoneal macrophages at 50 nM; a selective inhibitor of the NLRP3 inflammasome over the NLRP1, AIM2, and NLRC4 inflammasomes when used at 50 nM; decreases plasma levels of IL-1β, oxidized LDL autoantibodies, total cholesterol, and triglycerides, and reduces the size of atherosclerotic lesions in the aorta of mice fed a high-fat diet at 2.5 ng/g
-20°C
