AS-1892802
Catalogue number:
CAY14978-5 mg
Supplier:
Size:
5 mg
Product is available in:
£223.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
928320-12-1
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
333.4
Alternative Names:
n-[(1s)-2-hydroxy-1-phenylethyl]-n'-[4-(4-pyridinyl)phenyl]-urea
- Data sheet: View or download
- MSDS: View or download
Product Description:
A potent ROCK inhibitor (IC50s = 122, 52, and 57 nM for human ROCK1, ROCK2, and rat ROCK2, respectively); selective for ROCK1 and 2 over a panel of 167 kinases and a panel of 63 ion channels, receptors, and enzymes at a concentration of 10 µM; inhibits PKACα and PRKX (IC50s = 200 and 325 nM, respectively); reduces weight imbalance deficits (ED50 = 0.15 mg/kg) in rats in a monoiodoacetate-induced model of non-inflammatory arthritis; has analgesic-like effects in a rat model of streptozotocin-induced diabetic neuropathy; reduces cartilage damage and weight imbalance deficits in a rat model of osteoarthritis.
Storage Temperature:
-20°C
