£151.00
Estimated delivery Wed 7 Aug
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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
839706-07-9
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
547.5
Alternative Names:
n-[3-[1,4-dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2h)-yl]-4-methylphenyl]-3-(trifluoromethyl)-benzamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A multi-kinase inhibitor (IC50s = 25, 8, 61, 122, 136, and 133 nM for ACK1, GCK, Bcr-AblT315I, Bcr-AblE255V, Bcr-AblG250E, and c-Abl, respectively); inhibits the growth of Ba/F3 cells transformed with wild-type Bcr-Abl, Bcr-AblT315I, Bcr-AblE255V, and Bcr-AblG250E (IC50s = 50s = 1 and 5 nM, respectively); reduces tumor growth in a Bcr-AblT315I Ba/F3 mouse xenograft model at 10 and 20 mg/kg; reduces tumor volume in an OCI-AML3 mouse xenograft model at 8 mg/kg
Storage Temperature:
-20°C
