Acarbose
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56180-94-0
≥98%
A crystalline solid
645.6
o-4,6-dideoxy-4-[[(1s,4r,5s,6s)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-d-glucopyranosyl-(1→4)-o-α-d-glucopyranosyl-(1→4)-d-glucose, bay-g 5421
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- MSDS: View or download
An inhibitor of α-glucosidases (IC50s = 0.16 and 2.9 µM for maltase and sucrase, respectively); activates phosphorylase kinase in a cell-free assay at 250 µM; decreases urine levels of glucose and glycosylated hemoglobin, as well as glomerular mesangial thickening in a db/db mouse model of diabetic nephropathy at 40 mg/kg in the diet; reduces sucrose-induced increases in infarct size as a percentage of the area at risk and serum MDA levels in a mouse model of coronary artery ligation-induced cardiac ischemia-reperfusion injury at 10 mg/kg
-20°C
