(±)14-HDHA
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87042-40-8
≥98%
A solution in ethanol
344.5
(±)14-hydroxy-4z,7z,10z,12e,16z,19z-docosahexaenoic acid, (±)14-hdohe, 14-hydroxy docosahexaenoic acid
- Data sheet: View or download
- MSDS: View or download
(±)14-HDHA is an autoxidation product of DHA in vitro.{7479,7491} It is also produced from incubations of DHA in rat liver, brain, and intestinal microsomes.{7480,7490,7492} DHA is metabolized to 14(S)-HDHA by human platelets along with 11(S)-HDHA.{7483,7484,7492} 14(S)-HDHA is also produced by salmon gills upon stimulation with calcium ionophore.{7514} 14(S)-HDHA is an inhibitor of U-46619-induced human platelet aggregation and rabbit and rat aortic smooth muscle contraction with IC50 values of about 70, 3.6, and 5.3 µM, respectively.{7484,7481} (±)14-HDHA is a potential marker of oxidative stress in brain and retina where DHA is an abundant PUFA.
-20°C
