PF-01247324
Catalogue number:
CAY22111-10 mg
Supplier:
Size:
10 mg
Product is available in:
£229.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
875051-72-2
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
330.6
Alternative Names:
6-amino-n-methyl-5-(2,3,5-trichlorophenyl)-2-pyridinecarboxamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
An Nav1.8 sodium channel blocker (IC50 = 0.19 µM for human Nav1.8); selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 µM, respectively) as well as ERG potassium channels (IC50 = 30 µM); blocks Nav1.8 channels in a VSP-FRET assay using HEK293 cells (IC50 = 2.6 µM); reduces phase 2 flinching in a rat model of formalin-induced persistent pain at 100 mg/kg; increases latency to lift the inflamed paw and latency to paw withdrawal in rat models of carrageenan-induced thermal hyperalgesia and CFA-induced mechanical hyperalgesia, respectively
Storage Temperature:
-20°C
