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568-73-0
≥98%
A crystalline solid
276.3
1,6-dimethyl-phenanthro[1,2-b]furan-10,11-dione, tanshinone a
- Data sheet: View or download
- MSDS: View or download
A diterpene with diverse biological activities; inhibits proliferation in a variety of cancer cell lines, including multidrug-resistance cell lines; inhibits topoisomerase I- and topoisomerase II-mediated supercoiled DNA relaxation activity at 200 and 25 µM, respectively; inhibits proliferation of H358-IR and H157-IR radioresistant lung cancer cells (IC50s = 10.87 and 6.1 µM, respectively); reduces plasma levels of total cholesterol, triglycerides, LDL, and nonesterified fatty acids and decreases blood glucose levels in a rat model of streptozotocin and high-fat diet-induced type 2 diabetes; neuroprotective in an MPTP mouse model of Parkinson’s disease at 10 mg/kg per day for two weeks
-20°C
