3α-Aminocholestane
Catalogue number:
CAY27885-10 mg
Supplier:
Size:
10 mg
Product is available in:
£239.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2206-20-4
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
387.7
Alternative Names:
(3α,5α)-cholestan-3-amine, 3ac
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of SHP-1 (IC50 = ~2.5 µM); selective for SHP-1 over SHP-2 and PTEN (IC50s = >20 µM); induces hyperactivation of SYK in patient-derived Ph+ ALL cells; reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model at 50 mg/kg; reduces cell viability of OPM2 cells in a concentration-dependent manner and of RPMI8226 cells at ≥12.5 µM; halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively; induces apoptosis via activation of caspase-3, caspase-9, and PARP in OPM2 cells but not in RPMI8226 cells
Storage Temperature:
-20°C
