MX1013
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582316-00-5
≥98%
A solid
382.4
5-fluoro-3-[[(2s)-3-methyl-1-oxo-2-[[(phenylmethoxy)carbonyl]amino]butyl]amino]-4-oxo-pentanoic acid, z-val-asp-fluoromethyl ketone, z-vd-fmk
- Data sheet: View or download
- MSDS: View or download
A dipeptide pan-caspase inhibitor; inhibits caspase-1 (IC50 = 20 nM), caspase-3 (IC50 = 30 nM), and caspase-6, -7, -8, and -9 (IC50s = 5-18 nM); selective for caspases over calpain I, cathepsin B, cathepsin D, renin, thrombin, and Factor Xa (IC50s = >10 µM); inhibits anti-Fas antibody-induced caspase-3 processing and PARP cleavage in Jurkat cells at 0.05 µM; increases survival in a mouse model of anti-Fas antibody-induced liver failure at ≥0.25 mg/kg; reduces infarct size in rat models of acute myocardial infarction-reperfusion or transient focal brain ischemia-reperfusion injury intravenously as a 20 mg/kg bolus dose followed by a 5 mg/kg per hour infusion
-20°C
