Begacestat
Catalogue number:
CAY27916-1 mg
Supplier:
Size:
1 mg
Product is available in:
£73.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
769169-27-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
391.7
Alternative Names:
5-chloro-n-[(1s)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide, gsi-953
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of γ-secretase (IC50 = 15 nM for AAP cleavage to Aβ40); 14-fold selective for γ-secretase over Notch-1; reduces brain levels of Aβ40 and Aβ42 in the Tg2576 transgenic mouse model of Alzheimer's disease; also increases contextual fear conditioning freezing time in Tg2576 mice
Storage Temperature:
-20°C
