MRX-2843
Catalogue number:
CAY27923-10 mg
Supplier:
Size:
10 mg
Product is available in:
£432.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1429882-07-4
Purity:
≥95%
Formulation:
A crystalline solid
Molecular Weight:
488.7
Alternative Names:
trans-4-[2-[(2-cyclopropylethyl)amino]-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7h-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol
- Data sheet: View or download
- MSDS: View or download
Product Description:
A Mer and FLT3 inhibitor (IC50s = 1.3 and 1 nM, respectively); inhibits Axl and Tyro3 (IC50s = 15 and 17 nM, respectively); inhibits Mer phosphorylation in MOLM-14 and MV4-11 AML cells from 10-300 nM; reduces clonal expansion of Kasumi-1 AML cells (IC50 = 143.5 nM); increases survival in a NOMO-1 and MOLM-14 AML mouse xenograft models at 65 and 50 mg/kg, respectively
Storage Temperature:
-20°C
