Ecabet (sodium salt)
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86408-72-2
≥98%
A crystalline solid
402.5
(1r,4as,10ar)-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-6-sulfo-1-phenanthrenecarboxylic acid, monosodium salt, ta-2711
- Data sheet: View or download
- MSDS: View or download
An antiulcerative and gastroprotective agent; reduces the viability of H. pylori grown under urea-supplemented acidic conditions in a concentration-dependent manner; inhibits H. pylori urease activity in a pH-dependent manner (IC50s = 2.1-2.6 and >16 mg/ml at pH values of 5 and 8, respectively); inhibits adhesion of H. pylori to MKN-28 cells at 1 and 2 mg/ml; increases levels of PGE2 in rat gastric mucosa at 25 and 100 mg/kg, p.o. in vivo; inhibits formation of hemorrhagic lesions in esophageal mucosa and reduces gastric juice pepsin activity in a rat model of reflux induced by fore-stomach and pyloric ligation at 30 mg/kg
-20°C
