AUNP-12
Catalogue number:
CAY28053-1 mg
Supplier:
Size:
1 mg
Product is available in:
£199.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
1353563-85-5
Purity:
≥95%
Formulation:
A solid
Molecular Weight:
3261.6
Alternative Names:
n2,n6-bis(l-seryl-l-asparaginyl-l-threonyl-l-seryl-l-α-glutamyl-l-seryl-l-phenylalanyl)-l-lysyl-l-phenylalanyl-l-arginyl-l-valyl-l-threonyl-l-glutaminyl-l-leucyl-l-alanyl-l-prolyl-l-lysyl-l-alanyl-l-glutaminyl-l-isoleucyl-l-lysyl-l-α-glutamine, aur-012, s
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of the interaction between PD-1 and its ligands, PD-L1 and PD-L2; inhibits binding of soluble PD-1 to HEK293 cells expressing human PD-L2 (EC50 = 0.72 nM); reverses PD-L1-induced inhibition of proliferation of PMA-stimulated, PD-1-expressing rat PBMCs (EC50 = 0.41 nM); reduces tumor growth and lung metastasis by 44 and >60%, respectively, in a B16/F10 mouse melanoma model at 5 mg/kg per day
Storage Temperature:
-20°C
