Photoswitchable PAD Inhibitor (technical grade)
Catalogue number:
CAY28104-1 mg
Supplier:
Size:
1 mg
Product is available in:
£251.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2226393-62-8
Purity:
≥70% (mixture of isomers)
Formulation:
A crystalline solid
Molecular Weight:
488
Alternative Names:
n-[(1s)-1-(1h-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4-(2-phenyldiazenyl)-benzamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A photoactivated PAD inhibitor; a weak inhibitor of PAD2 (IC50 = >100 µM) and less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 for M-1min-1 for PAD1-4, respectively) without photoactivation; can rapidly be photoactivated with UV-A radiation to the more active cis-isomer, which is an irreversible, competitive inhibitor of histone H3 citrullination with an IC50 value of 9.1 µM
Storage Temperature:
-20°C
