This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2407433-00-3
Purity:
98.84
Molecular Formula:
C21H18N8
Molecular Weight:
382.42
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
T025 is an orally active and highly potent inhibitor of Cdc2-like kinase (CLKs), with Kd values of 4.8, 0.096, 6.5, 0.61, 0.074, 1.5 and 32 nM for CLK1, CLK2, CLK3, CLK4, DYRK1A, DYRK1B and DYRK2, respectively. T025 induces caspase-3/7-mediated cell apoptosis. T025 reduces CLK-dependent phosphorylation. T025 exerts anti-proliferative activities in both hematological and solid cancer cell lines (IC50 values: 30-300 nM). T025 has an anti-tumor efficiency, mainly for MYC-driven disease research[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
