This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2035814-50-5
Purity:
99.06
Molecular Formula:
C25H22FN5O2
Molecular Weight:
443.47
- Data sheet: View or download
- MSDS: View or download
- Protocol: View or download
Product Description:
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models[1].
Storage Temperature:
-20°C, 3 years; 4°C, 2 years (Powder)
