Lexogen

Lexogen are RNA specialists who develop technologies for RNA sequencing, provide services and bioinformatics analysis to help resolve the complexity of the transcriptome. 

Lexogen's unique proprietary expression profiling technologies enable the detailed analysis of the complete transcriptome, as well as individual full-length RNAs. With a strong focus on the sample preparation and data analysis component of the RNA-Seq workflow, Lexogen's portfolio includes kits for single-cell and bulk RNA-seq, RNA purification, ribosomal RNA depletion, metabolic RNA labelling and spike-in RNA variant controls.

QuantSeq expression profiling library prep kits
The QuantSeq family of kits have been cited in over 1600 publications since their launch in 2014 and have become the gold-standard solution for gene expression analysis. The kits provide a 5x decrease in sequencing costs compared to mRNA-seq and even work with FFPE and degraded samples.

QuantSeq 3’ mRNA-Seq kits generate Illumina compatible NGS libraries of sequences close to the 3’ ends of poly(A) RNA. One fragment per transcript is generated, enabling accurate gene expression quantification while saving sequencing depth and allowing for a high level of multiplexing.

CORALL™ total RNA-seq library prep kits
CORALL enables streamlined generation of Illumina-compatible libraries within 4.5 hours, featuring seamless integration of Unique Molecular Identifiers (UMIs) and exceptional protocol-inherent strand specificity (>99 %). The fragmentation-free protocol uses Lexogen’s proprietary Strand Displacement Stop and Ligation technologies to deliver complete transcript representation, including genuine transcription start sites.

For more information or to discuss your project, please contact our Lexogen specialists

Customer testimonial

"Working with Lexogen helped make the impossible very achievable. My work uses novel translation techniques to obtain physiologically relevant tissues from patients which yields less than 1 ng/ml of RNA material. This is often unquantifiable and quality is variable. I approached many RNA-seq providers and was told that this was impossible and not achievable.

I was introduced to Lexogen through Cambridge Bioscience and they helped me achieve what all of the main RNA-seq providers said was impossible. I was professionally guided through the whole process by the Lexogen team, starting with a pilot to assess quality.

From this they then recommended the right product that they made in house to help.

I subsequently submitted 40 patient samples for 3’ mRNA-seq of exceptionally low yield and variable quality. In return I received 40 full transcriptomic profiles which is fantastic. I am incredibly happy with the results, support and experience with Lexogen and I am now strictly a Lexogen customer for all my RNA-Seq needs."

- Charlie Piercy, Lead Clinical Research Practitioner, Royal Surrey NHS Foundation Trust & PhD Student, University of Surrey

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