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This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2314465-67-1
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
449.4
Alternative Names:
(3s)-2,3-dihydro-6-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methoxy]-3-benzofuranacetic acid
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual agonist of FFAR1/GPR40 (EC50 = 68 nM in a FLIPR assay) and PPARδ (102 nM in a reporter assay); selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both); reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease at 40 mg/kg; reduces hepatic steatosis and plasma ALT and AST levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at 40 mg/kg
Storage Temperature:
-20°C