CAY10763
Catalogue number:
CAY30593-5 mg
Supplier:
Size:
5 mg
Product is available in:
£769.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2364458-49-9
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
471.5
Alternative Names:
(αr)-α-[[1,4-dihydro-4-(hydroxyimino)-1-oxo-2-naphthalenyl]amino]-n-(3,5-dimethoxyphenyl)-benzenepropanamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A dual inhibitor of IDO1 and STAT3 activation (IC50 = 46 nM); binds to STAT3 (Kd = 530 nM); selectively reduces levels of phosphorylated STAT3Y705 over phosphorylated STAT3S727, STAT1, and STAT5 in SKOV3 cells at 500 nM; cytotoxic to HCT116, SKOV3, A549, and HepG2 cancer cells (IC50s = 37, 28, 33, and 12 nM, respectively); reduces tumor growth in B16/F10 mouse melanoma and HepG2 mouse xenograft models at 100 and 10 mg/kg, respectively
Storage Temperature:
-20°C