SW044248
Catalogue number:
CAY23459-25 mg
Supplier:
Size:
25 mg
Product is available in:
£284.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
522650-83-5
Purity:
≥98%
Formulation:
A crystalline solid
Molecular Weight:
421.5
Alternative Names:
2-[(5-ethyl-5h-1,2,4-triazino[5,6-b]indol-3-yl)thio]-n-(2-methoxyphenyl)-butanamide
- Data sheet: View or download
- MSDS: View or download
Product Description:
A DNA topoisomerase I inhibitor; exhibits selective cytotoxicity across a panel of 46 NSCLC lines (IC50s = ~2 µM for HCC4017, H292, and H1819 cells versus >20 µM for the remaining cell lines); induces cleavage of PARP and caspase-3 and blocks DNA replication, RNA transcription, and protein translation in susceptible-, but not resistant-, cells in a dose-dependent manner; inhibits the ability of recombinant topoisomerase 1 to relax supercoiled DNA; topoisomerase 1 knockdown rescues HCC4017 cells from SW04428 cytotoxicity; expression of CDKN1A reduces SW044248 cytotoxicity
Storage Temperature:
-20°C