AZD 1390
Catalogue number:
CAY36498-10 mg
Supplier:
Size:
10 mg
Product is available in:
£325.00
Estimated delivery Wed 7 Aug
Shipping is calculated in checkout
Shipping is calculated in checkout
This product is for research use only and is not for human consumption or therapeutic use.
CAS Number:
2089288-03-7
Purity:
≥98%
Formulation:
A solid
Molecular Weight:
477.6
Alternative Names:
7-fluoro-1,3-dihydro-3-methyl-1-(1-methylethyl)-8-[6-[3-(1-piperidinyl)propoxy]-3-pyridinyl]-2h-imidazo[4,5-c]quinolin-2-one
- Data sheet: View or download
- MSDS: View or download
Product Description:
An inhibitor of ATM kinase (IC50 = 0.78 nM); selective for ATM over ATR, PI3K, mTOR, and DNA-PK (IC50s = >30, >12, >16, and >29.9 µM, respectively); sensitizes glioma cells expressing mutant, but not wild-type, p53 to ionizing radiation; reduces the growth of brain metastases and increases survival in an NCI H2228 mouse xenograft model at 20 mg/kg twice daily, p.o., in combination with radiation
Storage Temperature:
-20°C